Objective To investigate effect of Tianma Gouteng particles combined with nifedipine and captopril in treatment of elderly with hypertension. Methods The elderly hypertensive patients that in our hospital from February 2010 to February 2012 were randomly divided into two groups， the control group was given nifedipine and captopril， the observation group was given Tianma Gouteng particles on the basis of the control group. The clinical efficacy， blood pressure that before and after treatment， and untoward effect were compared with the two groups. Results The total effective rate of the observation group was 94.57% significantly higher than 78.26% of the control group（χ2=10.42，P<0.05）； SBP and SDP after treatment in both groups was significantly lower than before， and the observation group were also significantly lower than the control group（P<0.05）； there were no incidence of adverse reactions between the two groups（P>0.05）. Conclusion Tianma Gouteng particles combined with nifedipine and captopril in the treatment of elderly hypertensive is significant， and it is safe， effective and worth to be promoted and applied in clinical.