Objective To evaluate the clinical efficacy of rhubarb combined with Western medicine octreotide treatment of acute pancreatitis， to evaluate its safety， aims to provide a reference value for clinical treatment. Methods A total of 124 cases of acute pancreatitis were randomly divided into a control group and observation group， 62 cases in each group. The control group received octreotide acetate injection treatment， observation group were based on the use of traditional Chinese medicine Rhubarb treatment. Observe and compare the clinical efficacy of the two groups of patients， APACHEⅡ score and AMY， （LIP and Leptin levels， etc.）（Note that both the hospital laboratory we did not do） Results The total effective rate was significantly higher， with statistics learn the difference（P<0.05）； after treatment APACHE Ⅱ scores were significantly lower than before treatment between the groups， and the observation group APACHE Ⅱ score was significantly lower than the control group， the differences were statistically（P<0.05）； observation AMY and LIP serum levels were significantly lower than the control group（P<0.05）， serum Leptin levels were significantly higher， with a statistically significant difference（P<0.05）； observation of fever， vomiting， abdominal pain， abdominal tenderness disappearance the symptoms and duration of hospitalization were significantly lower than the control group， with a statistically significant difference（P<0.05）. Conclusion Rhubarb octreotide treatment of acute pancreatitis significant effect， safe and reliable， can effectively inhibit the pathological changes of the pancreas and duration， improve patient outcomes， better than octreotide， worthy of clinical application.