Objective To investigate the clinical efficacy of the oral treatment of children with acute respiratory infections Lan Po to provide reference for clinical diagnosis and treatment. Methods The group of 72 cases of acute upper respiratory tract infection in children according to a random number table， randomly divided into control group（n=36） and treatment group（n=36）； intravenous cephalosporin group V pin， Lan Po in the treatment group taking oral；treatment lasted for taking 5d；analysis comparing the two groups of children with clinical efficacy after treatment. The results of the two groups of children with general information no statistical significant difference（P>0.05）， comparable. Results The total effective rate（94.44%） was significantly higher overall response rate（83.33%）， and has a significant difference（P<0.05）； sore throat disappeared after treatment time（2.41±1.04）d， cough time（3.10±1.18）d， cooling time（2.06±1.01）d were significantly shorter than the control group after treatment of sore throat disappearance time（4.27±1.26）d， cough time（4.96±1.20）d， fever clearance time（3.64±1.19）d， and there is a significant difference（P<0.05）； groups of children with no obvious adverse reactions during treatment. Conclusion The curative effect of Pudilan oral liquid in the treatment of children with acute upper respiratory tract infection significantly， the clinical symptoms can be significantly improved in patients， adverse reactions during treatment with a low incidence， high safety and no obvious adverse reactions， it has high application value in clinical treatment， can provide a new option for the treatment of children with acute upper respiratory tract infection.