Objective To study the effect of Fuzheng Xiegan decoction on the treatment of primary liver cancer and its immune function. Methods The subjects were 40 PHC patients in our hospital from October 2016 to June 2017， were treated with Fuzheng Xiegan decoction for 3 months. Tumor index， liver function index， KPS scores， pain degree， immune function index and traditional Chinese medicine（TCM） syndrome scores were detected before and after the treatment. Results After treatment， AFP， ALT， AST， TBIL and DBIL in patients were significantly lower than those before treatment， and TP levels were significantly higher than before treatment， the levels of CD3+， CD4+ and CD4+ /CD8+ were significantly higher than those before treatment， CD8+ was significantly lower than those before treatment（P<0.01）. The improvement rate of KPS score was 80.0%. In addition， the pain relief rate was 85.0%. The effective rates of all clinical symptoms were all over 60%. Conclusion Fuzheng Xiegan decoction treatment of primary liver cancer clinical significant effect， in particular， can reduce the early pain associated with cancer pain patients， improve immune function and promote the quality of life recovery.