Objective To observe the effect and clinical efficacy of Tripterygium Glycosides tablets combined with TCM classical formulas in the treatment of female patients with reproductive toxicity. Methods 40 cases of chronic nephritis patients were randomly divided into the treatment group and the control group， each group with 20 cases. The treatment group were treated with Tripterygium Glycosides tablets and four TCM classical formulas；control group with Tripterygium Glycosides tablets for half a year. To evaluate the plasma levels of sex hormones， urinary albumin and urine routine， clinical symptoms integral statistical and side effects between the two groups. Results menstrual disorders and sex hormone levels in plasma and descendance of sperm motility， The incidence of the treatment group was significantly lower than the control group（P<0.01）； and the urine albumin and urine， the treatment group was significantly lower than that in control group；the clinical symptoms improved significantly， reduce the side effects of reduced integration；there was significant difference between two groups（P<0.05）. There was no significant difference in the renal function among the two groups（P>0.05）， uric acid had significant difference among themselves（P<0.05）. Conclusion Tripterygium Glycosides tablets and four TCM classical formulas in the treatment of chronic nephritis can significantly reduce urinary protein， reduce reproductive toxicity， improve the clinical symptoms of patients， reduce side effects， improve efficacy.