Objective To investigate the clinical efficacy of Jianpi Qushi decoction in treating dampness of spleen deficiency of eczema. Methods 58 cases of eczema were selected， all were diagnosed as dampness of spleen deficiency of eczema，randomly assigned to the observation group and the control group， 29 cases in each group. The control group was given loratadine tablets treatment， the observation group was given Jianpi Qushi decoction for 3 weeks. The eczema area and severity index scale（EASI） was used to evaluate the skin lesions of the patients， and the EASI score， pruritus score， clinical efficacy were compared between the two groups. Results The total efficiency of the observation group was 96.55%， higher than 79.31% in the control group（P<0.05）； before treatment，compared two groups of EASI score， pruritus score， there was no significant difference（P>0.05）； after treatment， EASI score， pruritus score in the observation group were significantly lower than the control group （P<0.05）； there were no obvious adverse reactions in two groups. Conclusion Jianpi Qushi decoction is effective in treating dampness of spleen deficiency of eczema， and no obvious adverse reactions.