Objective To study the effect of Guizhi extract on the treatment of influenza virus pneumonia in rats and its mechanism. Methods 90 of Wistar rats aged 4 to 6 weeks were randomly divided into blank group （equal volume saline）， model group（equal volume saline）， ribavirin group（ribavirin 70 mg/kg， 0.2 mL/d）， The experimental group A（Guizhi extract 2 mL/kg， 1 day 1 times）， the experimental group B18 （Guizhi extract 4 mL/kg， 1 day 1 time）， using A/FM1/47（H1N1）Influenza virus virus model was established， and the corresponding intervention measures were given on the day of modeling. The serum inflammatory factors were detected and compared with each group after day 1， day 3 and day 7 The lung index of day 7， the expression level of P38， JNK and MKK4 protein in lung tissue. Results The lung index of the model group was significantly higher than that of the blank group（P<0.05）. The lung index of the virus group and the experimental group was significantly lower than that of the model group（P<0.05）. The levels of serum IL-1β， IL-6， IL-8 and TNF-α in the model group were significantly higher than those in the blank group（P<0.05） on the 1st， 3rd and 7th day after modeling（P<0.05）. The levels of IL-1β， IL-6， IL-8 and TNF-α in group A and B were significantly lower than those in model group（P<0.05）. The expression of P38， JNK and MKK4 protein in lung tissue of rats in model group was significantly higher than that in blank group（P<0.05）. The rats in group A and B The expression of P38， JNK and MKK4 protein was significantly lower in the tissue than in the model group（P<0.05）. Conclusion Guizhi extract treatment of influenza virus pneumonia rats can reduce the inflammatory response， reduce lung tissue P38， JNK and MKK4 protein expression levels， to achieve the purpose of treatment of influenza pneumonia.