Abstract:Objective To analyze the principles of Chinese medicine for chronic suppurative osteomyelitis (CSO)based on data ming. Methods Electronic retrieval of CNKI, Wanfang and VIP database, then extract the prescriptions of CSO. The data was analyzed by the Traditional Chinese Medicine inheritance support system(TCMISS). Results A total of 100 prescriptions, including 162 kinds of herbs, was analyzed. Four drugs, such as Jinyinhua, Huangqi, Danggui, and Gancao were most frequently used. Twelve herbs, which focus on tonifying qi and engendering blood, clearing heat and drawing out toxin, were commonly combined together. Jinyinhua, Pugongying, Zihuadiding, Gancao, Huangqi, Baizhu, Fuling and Danggui were in the core drugs correlation network. The qi and taste of Chinese herbs are mainly warm, cold, sweet, and bitter. The channels were mainly belong to liver, spleen and heart. At the same time, 11 new drug combinations were excavated. Conclusion The CSO treating from liver, spleen and heart. Specific methods including removing heat to eliminate toxins, benefiting qi to activate blood circulation and expelling pathogen. Antiphlogistic decoction of five drugs and decoction of four mild drugs were advocating to treat CSO.