Objective To investigate the effect of Fuzheng Chinese medicine combined with neoadjuvant chemotherapy in breast cancer. Methods We randomized operable breast cancer into chemotherapy group and Chinese medicine combined with chemotherapy group. The clinical and pathological effects， and expression of P-glycoprotein（Pgp）were observed between two groups. Results There was no difference in clinical effect between two groups. However， statistical difference existed in pathological effect. No significant pathological response was observed in Pgp-positive patients. The positive rates of Pgp was less in the combined group than that in the chemotherapy group. Statistical significance existed between two groups. Conclusion The expression of Pgp has a predictive effect on chemotherapy effect. Fuzheng Chinese medicine may reverse chemotherapy resistance through Pgp pathway. And it also improves the pathological response rate of neoadjuvant chemotherapy.