Objective The effects of Xuefu Zhuyu Decoction plus subtraction on limb swelling and platelet and D-two polymer after hip replacement were analyzed and analyzed. Methods 118 cases of total hip replacement in our hospital were randomly divided into 61 cases in the observation group and 57 cases in the control group. The control group was given the routine deep vein thrombosis（DVT） prevention program after operation. On this basis， the observation group gave the Xuefu Zhuyu Decoction plus subtraction treatment， and compared the degree of swelling of the limbs， platelet activation and plasma D-two polymer in the two groups. The velocity of venous blood flow in the affected limb and the incidence of DVT. Results after operation 3 d and 7 d， the swelling degree of the affected limbs was significantly lower than that before and after the operation（P<0.05）， and after after operation 3 d and 7 d the degree of swelling of the affected limbs observation group was significantly lower than that of the control group（P<0.05）. after operation 3 d and 7 d， the platelet activation index of GP IIb/IIIa and GMP-140 after operation in the observation group were significantly lower than that of postoperative 1 d （P<0.05）， and the observation group was lower than that of the control group（P<0.05）. The levels of plasma D-dimer in two groups after operation 3 d and 7 d lower than those after operation 1 d（P<0.05）， and the observation group was lower than the control group（P<0.05）. The total vein of limb femoral vein and deep femoral vein blood flow rate in the two groups after 3 d and 7 d after operation were significantly higher than that before operation（P<0.05）， and the observation group was significantly higher than that of the control group（P<0.05）. The incidence of postoperative DVT in the observation group was lower than that in the control group， but the difference was not statistically significant（P>0.05）. Conclusion Xuefu Zhuyu Decoction can effectively reduce the degree of limb swelling， decrease the activation of platelet and the level of plasma D-two polymer after hip replacement， improve the hypercoagulability of the body， and promote the velocity of venous blood flow after the operation， thus effectively preventing the occurrence of DVT.