Objective To analyze evaluation of curative effect and the law of choosing acupoints of acupuncture treatment for small breast disease. Methods The clinical literature on the treatment of small breast disease is collected from China National Knowledge Infrastructure（CNKI）， SinoMed， VIP Database for Chinese Technical Periodicals and China Science Periodical Database. We extracted the efficacy and site selection information included in the literature， established acupuncture clinical database of small breast disease， and used the data mining technology to analyze and select the highest frequency used acupoints， acupoints site and meridians. We explored and summarized the potential rule of modern acupuncture in the treatment of small breast disease. Results 10 clinical trials of treating small breast disease by acupuncture are selected. The curative effect of acupuncture and moxibustion is better than that of other treatments. 36 acupoints are involved， and the frequency of total acupoints is 102 times， the acupoints with the higher acupoint frequency are Sanyinjiao（SP6）， Zusanli（ST36）， Danzhong（RN17）， Rugen（ST18）， Taichong（LR3）. The Stomach Meridian of Foot-Yang ming and the Spleen Meridian of Foot-Tai yin are commonly used， commonly used part is the leg and cheast， commonly used specific acupoints are the crossing points， the front-mu points， the shu-points and the original points. Conclusion Acupuncture treatment for small breast disease is mainly based on the Stomach Meridian of Foot-Yang ming and the Spleen Meridian of Foot-Tai yin and attach importance to the application of the crossing points， the front-mu points， the shu-points and the original points. The combination of the local acupoints with the distal ones is predominated.