Objective To explore the clinical efficacy of Yiqi Yangyin Huoxue Decoction combined with propafenone in the treatment of arrhythmia， and to analyze the effect of it on serum hypersensitivity C- reactive protein（hs-CRP）. Methods 92 cases of arrhythmia in our hospital from June 2015 to December -2017 were selected and randomly divided into the study group and the control group， 46 cases in each group. The patients in the control group were treated with propafenone. On this basis， the patients in the study group were treated with Yiqi Yangyin Huoxue Decoction. After the treatment， the clinical efficacy of two groups of patients was evaluated. The changes of cardiac function index and serum hs-CRP level in the two groups before and after treatment were compared， and the incidence of adverse reactions in the two groups was observed. Results The total effective rate of the study group and the control group was 93.48% and 71.74% respectively， and the difference of the two groups was statistically significant（P<0.05）. After the treatment， the LVESD and LVEDD of the study group and the control group were lower than those before the treatment， and the LVEF was higher than that before the treatment（P<0.05）， and the LVESD and LVEDD in the study group were lower than those in the control group， LVEF was higher than that of the control group. In the control group（P<0.05）， the level of hs-CRP in the study group and the control group was lower than that before the treatment， and the level of hs-CRP in the study group was lower than that of the control group（P<0.05）， and the incidence of adverse reactions in the study group was significantly lower than that of the control group（P<0.05）. Conclusion Yiqi Yangyin Huoxue Decoction combined propafenone in the treatment of arrhythmia clinical effect is significant， can reduce the level of hs-CRP， improve the patient’s heart function， and high safety， worthy of clinical promotion.