Objective To discuss the effectiveness and safety of Fuzi Lizhong decoction in the treatment of ulcerative colitis. Methods Databases such as PubMed， The Cochrane Library， Embase， Web of Knowledge， Allied and Complementary Madicine， OpenGrey， CBM， Wanfang Data， VIP and CNKI were searched for the randomized controlled trials（RCT）about Fuzi Lizhong decoction combined with western medicines and western medicine in treating ulcerative colitis from database creation to May 15th， 2018. Their qualities were assessed by the Cochrane scale. The therapies， sample size， clinical efficacy， endoscopic improvement and adverse events of the included literatures were collected. A Meta-analysis was made on the efficacy and adverse events. Results A total of 8 studies involving 730 patients were included. The results of Meta-analysis showed that， compared with western medicines， Fuzi Lizhong decoction and Fuzi Lizhong decoction combined with western medicines the combined RR of the effective rate of 1.20[95% CI（1.08， 1.32）]， 1.22[95% CI（1.12， 1.33）]， with statistical significance（P<0.05）， and significantly reduce the incidence of adverse reactions. The sensitivity analysis and funnel plot analysis showed a higher homogeneity in the literatures and no evidence of publication bias. Conclusion Compared with western medicines， Fuzi Lizhong decoction and Fuzi Lizhong decoction combined with western medicines is batter than western medicines in terms of curative rate and adverse reactions. But it still needs more large-sample-size double-blind RCTs shall be included to support this conclusion.