Objective To analyze the relationship among TCM Syndrome， clinical pathology and prognosis of pFSGS. Methods One hundred and two patients with pFSGS in the Department of Nephrology between 1996 and 2012 were retrospectively studied. We analyzed the relationship among TCM Syndrome， clinical pathology and prognosis of pFSGS. Results 1） All the 102 pFSGS patients have mailuoyuzu syndrome， without single syndrome. Among them， 66 patients have bigeminy syndrome， accounting for 64.7%， wherein qiyinliangxu， mailuoyuzu syndrome（qiyin-united syndrome） accounting for 23.5%， fengshineirao， mailuoyuzu syndrome（fengshi-united syndrome） accounting for 41.2%. 36 patients have sheqiyinliangxu， mailuoyuzu， fengshineirao（triad syndrome）， accounting for 35.3%. 2） Fengshi-united syndrome and triad syndrome are both higher in urinary protein， the proportion of NS patients， urinary NAG/Cr， serum total cholesterol， HDL， LDL， than that in qiyin-united syndrome（P<0.05）. But they are lower in serum albumin， IgG levels than that in qiyin-united syndrome（P<0.05）. 3） The IgM immune deposition rate in fengshi-united syndrome is 76.3%， higher than qiyin-united syndrome（P<0.05）. 4） Collapsing variant have two cases， each of them has fengshi-united syndrome and triad syndrome. The tip FSGS has 4 cases with fengshi-united syndrome. 5） Five cases in the follow-up patients with normal baseline serum creatinine progressed to endpoint events， among them have fengshi-united syndrome in two cases and triad syndrome in three cases. However， the survival rates of these three groups syndrome are not significant difference（P>0.05）. Conclusion PFSGS patients all have mailuoyuzu syndrome， without single syndrome. The qiyin-united and fengshi-united syndromes are the main syndrome types. Fengshi-united syndrome and triad syndrome groups have serious clinical manifestation， and maybe have a worse outcome.