Objective Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis（AM） combined with infertility. Methods There were 60 cases of patients who were diagnosed with uterine AM combined with infertility and their syndrome differentiation of traditional Chinese medicine（TCM） belonged to cold blood coagulation and blood stasis， which were randomly divided into treatment group and control group with 30 cases in each group. The treatment group was gave the combination of Thunder-Fire moxibustion and ovulation monitoring， while the control group was only treated with ovulation monitoring. The pregnancy rate， the improvement of dysmenorrhea symptoms and TCM syndromes， and the changes of serum CA-125 and uterus diameter in 6 menstrual cycles were compared between the two groups. Results The pregnancy rate in the treatment group was statistically significant compared with the control group（P<0.05）. The dysmenorrhea symptoms and TCM syndromes in the treatment group improved significantly. Compared with the control group， the difference was statistically significant（P<0.05）. There was a significant difference in serum CA-125 between the two groups（P<0.05）. There was no significant difference in the average diameter of the uterus compared with the control group（P>0.05）. Conclusion Thunder-Fire moxibustion combined with ovulation monitoring was an effective method to improve the pregnancy rate of patients with AM.