Objective To study the derivatives of Panaxadiol and its diastolic vaso activity. Methods Panaxadiol derivatives were synthesized by acylating reagents and cinnamyl acylating reagents， and their structures were confirmed by NMR and LC-MS. Results One Panaxadiol derivative and nine Panaxadiol cinnamic acid derivatives were synthesized， and none of them has been reported in the literature. Compounds 1，3，4，7 was found to have certain vasodilatory activity. Conclusion Compounds with diastolic vasoactivity were screened， and these compounds deserve further study.