Objective To explore the clinical efficacy and safety evaluation of Shugan Jianpi Yangxin decoction for functional dyspepsia（FD） patients with liver depression and spleen deficiency. Methods 108 FD patients with liver depression and spleen deficiency were divided into three groups by random number table. 36 cases in the experimental group， 36 cases in the control group and 36 cases in the basic group were treated with Shugan Jianpi Yangxin decoction+domperidone， Shugan Jianpi decoction domperidone， traditional Chinese medicine simulator+Domperidone for 12 weeks， and finally 99 cases were included， including 34 cases in the experimental group， 33 cases in the control group and 32 cases in the basic group. The symptoms of traditional Chinese medicine， SF-36 life scale， Hamilton Anxiety Scale（HAMA）， Hamilton Depression Scale（HAMD） and medication safety were observed before and after treatment in patients with functional dyspepsia（FD） accompanied by anxiety and depression. Results The experimental group can significantly improve the symptoms of FD patients with anxiety and depression of liver depression and spleen deficiency type. It is better than the control group and the basic group in improving postprandial abdominal distention， poor appetite， depression or irritability， fatigue. In terms of SF， RE and MH， the curative effect is better than that of the control group and the basic group； And the experimental group can significantly improve the anxiety and depression state of patients， its curative effect is better than that of the control group and the basic group；in terms of safety， the experimental group is safe in clinical usage， and no toxic reaction is found. Conclusion Shugan Jianpi Yangxin decoction is effective， safe and worth popularizing.