Objective To evaluate the efficacy and safety of Yiqi Yangyin Huoxue in the treatment of DKD. Methods The literature of the randomized clinical controlled trial（RCT） for the treatment of DKD was retrieved from the electronic periodical database in the past 10 years. The databases involved include the Chinese Journal Full Text Database（CNKI）， the Vip Chinese Science and Technology Journal Full Text Database（VIP）， the China Biomedical Documentation Database（CBM）， and the Wan Fang Chinese Medical Association Digital Journal. Manual retrieval. The methodological quality included in the literature was independently assessed by two researchers using the Jadad quality evaluation form as a reference. Meta analysis of the incorporated literature was carried out through the software RevMan 5.3， and the drawing of forest map and funnel map was completed. Results In the end， 23 documents were included， involving a total of 1920 patients. Meta analysis showed that the total therapeutic efficiency， apparent efficiency and ineffectiveness of the two groups were statistically different after treatment， but there was no significant difference between the two groups. At the same time， the clinical efficacy of ACEI or ARB drugs in treating DKD is also better than that of ACEI or ARB drugs alone. The symmetry of the funnel diagram is good， and there is no serious adverse effect. Conclusion It is effective and safe to treat DKD by Yiqi Yangyin Huoxue. However， due to the limited number of literature samples included in this study and the low quality of literature， more in-depth verification work needs to be carried out with large samples and high-quality RCT.