Objective Based on database mining Chinese medicine for the treatment of cirrhosis and ascites， and to discover new prescriptions. Methods From the China Knowledge Network， Baidu Academic， Weipu Chinese Journal Database， Wanfang Medical Database， PubMed database to collect prescriptions on the treatment of cirrhosis ascites in Chinese medicine， using Excel2007 to build data sets and standardize Chinese medicine naming， enter the Chinese medicine inheritance platform The software（TCMISS V2.5） was used for data analysis to obtain the rule of traditional Chinese medicine for treating cirrhosis and ascites. Results A total of 201 prescriptions were included. The traditional Chinese medicine with frequency ≥16 times has 64 flavors. It is mainly used for replenishing medicine， water-sparing osmotic medicine， promoting blood circulation and removing phlegm medicine， and qi medicine. The taste is cold， warm， flat， sweet and bitter. Mainly due to sin， mainly to the liver， spleen， stomach， lung， 83 strong drug association patterns， 102 pairs of commonly used drugs， 13 candidate new parties by entropy hierarchical cluster analysis. Conclusion Modern medical doctors treat cirrhosis ascites with “over-the-counter and application” as the rule of cure. The treatment focuses on spleen-reinforcing qi， dilute water and phlegm， promoting blood circulation and removing blood stasis， supplemented by Xuanfei solution， clearing heat and qi， digestion and stagnation. The law.