Objective To observe the effects of Wenshen Huatan decoction on the expression of Orai1， Caspase3， Caspase9， Bax and Bcl-2 genes and their related proteins in atherosclerotic vulnerable plaque models of ApoE knockout mice. Methods The model of atherosclerotic vulnerable plaque in ApoE knockout mice was established and randomly divided into six groups， like blank control group， vulnerable plaque group， positive control group， Wenshen Huatan decoction low， medium and high dose groups. After 13 weeks， the mice were sacrificed by anesthesia. The expressions of Oria1， Caspase3， Caspase9， Bax and Bcl-2 genes in aortic smooth muscle cells were detected by RT-PCR technology. The expressions of protein associated with the above genes in the aortic sinus were also detected by Western blot technology. Results Compared with blank control group， the expression levels of Orai1， Casepase3， Casepase9 and Bax mRNA and protein in the vulnerable plaque group increased significantly（P＜0.01）， while the ones of Bcl-2 decreased significantly（P＜0.01）. Compared with the vulnerable plaque group， the mRNA and protein expression of the above genes（excluding Bcl-2） in the positive control group and Wenshen Huatan decoction group were down-regulated， and simultaneously the expression of Bcl-2’s mRNA and protein were up regulated. It’s also could be observed that the higher the dosage of the decoction， the more obvious the adjustment effect. Compared with the positive control group， the expression of those genes and protein in the high-dose group of Wenshen Huatan decoction were almost in the same. Among these two groups and blank control group， there was no statistically significant difference in the expression of those genes and proteins. Conclusion Wenshen Huatan decoction can prevent the formation and progression of vulnerable plaques by regulating the expression of relational genes and proteins， and thus protect the cardiovascular system.