Objective To investigate the characteristics and pathogenesis of TCM syndromes in patients with type 2 diabetes mellitus（T2DM） complicated with diabetic peripheral neuropathy（DPN）. Methods From January 2018 to December 2018， 189 patients with T2DM complicated with DPN were collected from the health service center of Tongling road and Sanlian street in Hefei city. The TCM syndrome scale was used to investigate and analyze the TCM syndrome characteristics of DPN patients as well as the pathogenic factors of the syndrome of deficiency of Yin and Yang combined with phlegm and dampness. Results （1） The frequency of single syndrome was 102 cases of qi deficiency（53.96%）， 89 cases of Yin deficiency（47.08%）， 69 cases of blood stasis（36.5%）， 49 cases of phlegm-dampness syndrome（25.92%）， 44 cases of blood deficiency syndrome（23.28%）， 40 cases of heat syndrome（21.16%）， and 21 cases of Yang deficiency syndrome（11.11%）. The frequency of moderate Yin deficiency， blood stasis and Yang deficiency increased significantly（46.66%， 44.44%， 9%）. Severe Yin deficiency syndrome and blood stasis syndrome were the highest（55.88%， 58.82%）. （3） the occurrence rate of mild single syndrome was up to 51.05%， and the frequency of moderate and severe composite syndrome was up to 93.55% and 100%， respectively. （4） there are 26 types of syndrome combinations， with a relatively high incidence of mild mid-qi deficiency（8， 17.02%）. There were 17 cases（18.27%） with moderate qi and Yin deficiency. The incidence of severe deficiency of Yin and Yang and blood stasis syndrome was higher in 10 cases（20.4%）. （5） multivariable logistic regression analysis showed， age and duration of Toronto scale score of Yin and Yang are two risk factors of phlegm and blood stasis syndrome. Conclusion Qi deficiency syndrome， Yin deficiency is the highest rates of TCM syndrome， with the progress of the DPN lesion degree， from qi and Yin deficiency syndrome of TCM syndrome types will be moving in the two virtual clip phlegm and blood stasis syndrome of Yin and Yang， and disease course， age and Toronto， score is the key factor.