Objective To observe the intervention of Pingchuanning on the related proteins in PI3K-Akt/PKB signaling pathway to explore the mechanism of airway remodeling in asthma. Methods A total of 105 male Sprague-Dawley rats were randomly divided into normal group, model group, Pingchuanning high-dose group, Pingchuanning middle-dose group, Pingchuanning low-dose group, Guilong Kechuanning group and ground plug. Rice pine group, 15 in each group. The pathological changes of rat lung tissues were observed by HE staining. The expression levels of ASK1 and TSC1 were detected by RT-qPCR. Results After HE staining, the bronchial structure of the model group was changed compared with the normal group. A variety of inflammatory cell infiltration, mucus plug and tracheal smooth muscle hyperplasia were observed, and the drug group had different degrees of improvement. RT-qPCR detection: Compared with the normal group, the amplitude of ASK1 up-regulation was the most significant in the model group(P<0.01). Compared with the model group, the expression of ASK1 was lower in the high-dose group of Pingchuanning than in the other groups(P<0.01). Compared with the normal group, the model group had the most significant down-regulation of TSC1(P<0.01). Compared with the model group, the high-dose group of Pingchuanning had the most significant up-regulation of TSC1 expression(P<0.01). The up-regulation of TSC1 expression was higher in the group than in the middle and low-dose groups (P<0.01). Conclusion Pingchuanning can alleviate airway inflammation in rats with cold asthma by regulating ASK1 and TSC1 in PI3K-Akt/PKB signaling pathway in rats with cold asthma, reduce airway hyperresponsiveness, and relieve gas. Road remodeling achieves the effect of asthma treatment.