Objective To evaluate the clinical efficacy of Wilson's disease Bushen Huoxue Huazhuo Co-western medicine. Methods We searched in 1995-2019 years has published database on the Bushen Huoxue Huazhuo Co-conventional western medicine treatment (treatment group) and conventional Western medicine treatment alone (control group) treatment of randomized controlled trials of Wilson's disease( randomized controlled trial, RCT). Cochrane risk of bias tool for assessing the quality of literature, RevMan5.3 software for Meta analysis. Results Finally, eight RCT, a total of 507 cases of patients. Meta analysis showed that: Compared with western medicine alone, Bushen Huoxue Huazhuo decoction combined with Western medicine can improve the clinical efficacy (RR=1.34,95% CI：[1.20, 1.49], P<0.00001), the test for heterogeneity I2=24%. Conclusion Chinese medicine Bushen Huoxue Huazhuo Co-treatment of Wilson's copper discharge performance becomes effectively improve clinical outcomes. But the quantity and quality of RCTs included in the restrictions, this conclusion still need large samples, high-quality randomized controlled trials be corroborated.