The pathogenesis of chronic renal failure (CRF) can be summarized as deficiency in the root and enrichment in the branch. On the one hand, the deficiency of spleen and kindey is the internal condition of the disease, on the other hand, dampness, heat dampness, blood stasis, turbidity toxin are the branch. In terms of treatment, the professor Tang ShuiFu make good use of Tongluo especially, which mainly includes activating blood circulation and removing blood stasis, dredging the collaterals by insects, and dredging the collaterals by resolving hard lump, providing a new idea for the treatment of chronic renal failure (CRF) with traditional Chinese medicine.