Objective Collected published literature about the post-stroke spasticity since 1979 to explore the medication rule post-stroke spasticity. Methods EpiData 3.1 was adopted to establish the database of post-stroke spasticity, frequency analysis, factor analysis and cluster analysis were performed by SPSS 20.0. Results A total of 107 articles were included, involving 68 prescriptions, 129 drugs, and the total frequency of the drugs was 1 078 times. There were high frequency drugs 28, and the most frequently used drugs were Radix Paeoniae Alba, the major used drugs were drugs of invigorating the circulation of blood and drugs of enriching the blood. 10 common factors were obtained by factor analysis and four groups were obtained by cluster analysis. Conclusion Yinxuekuixu, luomaiyuzu, Qixuekuixu, luomaiyuzu and Xuexujin-maishiyang are the principal syndromes of post-stroke spasticity. Radix Paeoniae Alba is the most important drug for the treatment of post-stroke spasticity. Papaya, Lycopodium clavatum, Millettia are the mainly symptomatic treatment drugs.