Objective To discuss the characteristics of medicine and the law of medicine use in Medical Origin.Methods This paper expounds the idea of treating eye diseases with liver from the aspects of the property and flavor, texture, meridians, compatibility and contraindication of the drugs used for treating eye diseases in Medical Origin, so as to get the regularity of using drugs. Results The characteristics of drugs for treating eye diseases in Medical Origin include the property and flavor complies with the method of liver's desire or not to replenish and purge, light texture can follow liver meridian up to the eye connector,all belong to the liver meridian that can replenish or purge liver, often combined with wind medicine or match with assistant and guide to treat liver and using diuretics with caution to protect liver yin. Conclusion The characteristics of medicine for treating eye diseases in Medical Origin can embody Zhang's idea of treating diseases from liver, he combined the performance characteristics of drugs with the physiological characteristics of the zang-fu organs,enriched and improved the theory of viscera syndrome differentiation, which had a profound impact on later generations.