Objective To observe the clinical efficacy of Professor Li Qi's Yinpu Bazheng San combined with Cefaclor capsule in the treatment of recurrent urinary tract infections in female patients with downward flow of damp and heat. Methods A total of 80 female patients diagnosed with RUTI in our hospital from December 2016 to February 2018 were randomly divided into treatment group and control group. According to the drug susceptibility test, the sensitive antibiotic was treated for 2 weeks until the urine routinely turned negative, and then the oral Cefaclor capsule was taken to maintain the treatment for 6 weeks in the control group. On this basis, the treatment group was treated with Yinpu Bazheng Powder orally. The treatment continued 8 weeks. The peripheral blood T lymphocyte subsets, clinical symptom relief time, clinical symptom disappearance time, TCM symptom score and efficacy were observed. Results After 1 week of treatment and at the end of treatment, the scores of TCM in the treatment group were significantly improved than those in the control group. The time of symptom relief and the disappearance time of symptoms were significantly lower than those of the control group. The improvement of CD4+, CD8+ and CD4+ /CD8+ in the peripheral blood of the treatment group was obviously. Compared with the control group, the differences were statistically significant(P<0.05). Conclusion Self-made Yinpu Bazheng San combined with antibiotics were effective in the treatment of recurrent urinary tract infections in female patients with downward flow of damp and heat. It is worthy of clinical promotion.