Objective To observe the effect of RouGan decoction combined with entecavir in the treatment of patients with liver fibrosis induced by hepatitis B. Methods 60 patients with liver fibrosis induced by hepatitis B in our hospital were selected and divided into control group(30 cases) and treatment group(30 cases). The control group was treated with entecavir and the treatment group with RouGan decoction combined with entecavir, treated for 3 months. The clinical curative effect, serum liver function index and 1iver stiffness measurement, before and after the treatment were compared between the two groups. Results The total effective rate of the treatment group was 86.67%, which was higher than 63.33% of the control group. After treatment, liver function index, 1iver stiffness measurement in the treatment group were all better than those in the control group(P＜0.05). Conclusion RouGan decoction combined with entecavir had a good therapeutic effect on the treatment of liver fibrosis induced by hepatitis B, it could both improve the liver function and the life quality of patients.