Objective Using network pharmacology to analyze the molecular mechanism of Liuwei Dihuang Pills in treating coronary heart disease. Methods Obtained all chemical constituents and targets related to 6 traditional Chinese medicines in Liuwei Dihuang Pills from the Traditional Chinese Medicine Systems Pharmacology Analysis Platform (TCMSP). Cytoscape 3.2.1 software was used to construct a network map of compound target interactions. TTD, Drugbank, and DisGeNET databases were used to screen coronary heart disease-related disease targets. Venn analysis of coronary heart disease targets and drug targets were performed to screen out the common targets. Protein-protein interaction (PPI) network model was constructed by STRING platform. Gene Ontology (GO) enrichment analysis and KEGG pathway enrichment analysis of common targets of diseases and drugs were conducted by DAVID (Version 6.8) database. Results A total of 43 major components of Liuwei Dihuang Pills and 85 key targets related to the treatment of coronary heart disease were screened. The targets are mainly related to the regulation of lipopolysaccharide metabolism, inflammatory reaction, cell division, cytokine activity, DNA replication and transcription. Treatment coronary heart disease by participating in TNF, HIF-1, PI3K/Akt, Estrogen, TLRs, NF-κB, cGMP-PKG, cAMP and other signaling pathways. Conclusion This study explored the possible mechanism of Liuwei Dihuang Pills in the treatment of coronary heart disease from various perspectives, and revealed that Liuwei Dihuang Pills has the characteristics of multi-component, multi-target and multi-channel treatment of diseases, laying a foundation for its clinical application and further study of its pharmacodynamic mechanism.