Objective To obtain the potential target genes of ginseng-Indian Bread drugs for treating diseases through bioinformatics analysis, and to mine the genetic data chips of colorectal cancer patients and healthy people, and to predict the potential mechanism of ginseng-Indian Bread drugs for the treatment of colorectal cancer. Methods The GSE128449 gene chip was obtained from GEO database. The GEO2R online analysis software was used to set P<0.01, log2FC>1.5, and the differential genes were obtained. The bioinformatics analysis tool BATMAN-TCM (A Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine) set the candidate target score >20, P<0.05, obtained the compounds and target genes of ginseng-Indian Bread pair that may be interfered, and the two take the intersection to obtain the target genes for colorectal cancer. The target interaction(PPI) network model was constructed by using the PPI analysis database STRING, the network was constructed by using Cyotoscape mapping software, the Hub (core) gene network analysis was performed by the CytoHubba plug-in, and the path enrichment (KEGG) analysis and biological process (GO) analysis were performed by the R language Bioconductor package. Results In this experiment, 890 genes with high CRC significance(P<0.05) were obtained from GEO2R, and 293 compounds of Ginseng were obtained from BATMAN-TCM database (138 compounds had no structural information), and 1338 target genes might be interfered. Indian Bread acquired 54 compounds (33 of which have no structural information) may be involved in 503 target genes. A total of 23 genes were obtained including LEP, APOE, HTR3A, NPPA, TNF, PTGS2, HMBS, CREB1, AKR1C1, NFKB1, COX5A, RXRA, CAMK2D, PPARG, HDAC9, GABRA2, IL6, MAOB, NFIB, RAB3B, GRIN1, ADK, RRM2B. These genes were involved in the GO biological process such as active regulation of metabolic processes, regulation of inflammatory response, apoptosis, cell death, and negative regulation of cell proliferation. Also they regulate TNF signaling pathway, PI3K/Akt Signal pathways, NF-κB signaling pathways and transcriptional disorders in cancer. Conclusion Ginseng-Indian Bread may prevent and treat colorectal cancer by interfering with TNF, NFKB1, IL6, PTSG2 and other cancer-related and inflammation-related pathways.