Objective To explore the efficacy and safety of traditional Chinese medicine combined with clomiphene in the treatment of ovulatory infertility, and to provide a basis for clinical application. Methods The computer searches Chinese and English databases such as China national knowledge infrastructure（CNKI），Wanfang Database, VIP Database and PubMed. The language is Chinese or English. The search time is built until May 17, 2019. The search is based on the combination of subject words and free words. According to the inclusion criteria and exclusion criteria, the search literature was searched, the outcome indicators were extracted, and RevMan 5.3 software was used for statistical analysis. Results A total of 1 043 articles were searched, and 23 meta-analytic articles were included, 2 010 patients, including 1 054 in the treatment group and 956 in the control group. Meta-analysis showed that traditional chinese medicine combined with clomiphene in the treatment of ovulatory infertility patients with endometrial thickness[OR=1.77, 95%CI(1.34, 2.21)], pregnancy rate[OR=1.82, 95%CI(1.64, 2.02)], abortion rate[OR=0.19, 95%CI(0.09, 0.41)], better than the simple application of clomiphene, improve the ovulation rate[OR=0.04, 95%CI(-0.09, 0.17)], comparable to clomiphene. Sensitivity analysis suggests robust results.