Objective To analyze the rules of the prescription of removing phlegm and blood stasis in the treatment of prolactin type pituitary tumor. Methods 348 cases of primary diagnosis of prolactin pituitary adenoma were collected, and the frequency of drug use, association rules and core drug combination were analyzed by using v2.5. Results 66 traditional Chinese medicines were involved in the first 348 prescriptions, and Suning formula was used as the basic formula of resolving phlegm and removing blood stasis. Conclusion Based on the basic method of resolving phlegm and removing blood stasis, this paper preliminarily reveals the rule of prescription medication of prolactin pituitary adenoma treated with syndrome compatibility, provides objective methods for summarizing the clinical medication experience of the research group, and helps to provide new ideas for the treatment of prolactin pituitary adenoma by TCM.