Objective This work was conducted to observe the curative effect of Danzhi Jiangtang Capsule combined with Valsartan on early diabetic nephropathy. Methods 80 patients with early diabetic nephropathy in the Department of Endocrinology, Anhui Provincial Hospital of Traditional Chinese Medicine from June, 2018 to May, 2019 were chosen, randomly divided into study group and control group, 40 cases each. On the basis of the treatment of Valsartan (control group), the study group was additionally treated with Danzhi Jiangtang Capsule (treatment group) . Results The efficacy and total effective rate of TCM syndromes in the study group were better than those in the control group. The blood glucose levels of FPG、2hPG、UAER、NAG、mALB、BUN、and SCr in the study group were more obvious than those in the control group. The urine protein index also showed a certain decrease. Conclusion Danzhi Jiangtang Capsule can improve the efficacy in the treatment of early diabetic nephropathy.