Objective To observe the effect caused by ureteral calculi of renal colic with wrist-ankle acupuncture. Methods A total of 56 patients with renal colic caused by ureteral calculi admitted to the hospital of Wuhan Chinese Medicine Hospital from May 2018 to August 2019 were randomly divided into the wrist-ankle acupuncture group and the conventional western medicine group.Conventional Western medicine treatment group: Diclofenac sodium suppository （50mg） anal, patients with severe pain were given intramuscular analgesia with Tramadol injection （100mg）, and combined with racemic anisodamine injection （654-2） 10mg intravenous infusion treatment; Wrist-ankle acupuncture treatment group: The acupuncture ankle analgesia treatment of the lower 2 and lower 5 points was selected, and the needle retention time was 1.5 hours. The pain relief and clinical efficacy of renal colic were compared between the two groups. The pain visual analogue scale（VAS） was scored in both groups. The patients in the two groups were estimated for 5 min, 10 min, 15 min, 30 min after treatment. Assessment of pain relief at 45 min and 60 min. Results There was no greatly difference in VAS scores between the two groups after 5 minutes of renal colic treatment（P＞0.05）. The VAS score of the wrist-ankle acupuncture group was lower than that of the conventional Western medicine group in 10 min after treatment）（P＜0.05）; There was no remarkable difference in VAS scores between the two groups at 15 min, 30 min, 45 min, and 60 min after treatment（P＞0.05）; For renal colic in the wrist-ankle acupuncture group, the pain relief and disappearance time was significantly shorter than the conventional Western medicine treatment group.The difference was statistically significant（P＜0.01）; the total effective rate of the wrist-ankle acupuncture treatment group was 85.7％（24/28）, 75.0％ compared with the conventional Western medicine treatment group. （21/28）（P＜0.05）. The effect was more advantageous. Conclusion The effect of wrist and ankle acupuncture on ureteral calculi is definite.It is worth popularizing in clinic practice.