Objective To predict the potential target and mechanism of Yinqiao Powder in the treatment of upper respiratory tract infection(URTI) by network pharmacology. Methods The active components and related targets of Yinqiao were screened by traditional Chinese medicine system pharmacology database and analysis platform(TCMSP), the disease-related targets of URTI were searched by OMIM database and GeneCards database. Then get the intersection targets of Yinqiao Powder and URTI. The protein-protein interaction(PPI) network was constructed with STRING database, and the visualization of “component-disease-target” network was realized by Cytoscape software. Gene ontology(GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were carried out by DAVID database to predict its potential mechanism. Results 150 active components and 117 “drug-disease” common targets were obtained from Yinqiao Powder. The main active ingredients include(-) -phillygenin, luteolin, quercetin, kaempferol, forsythinol, stigmasterol, etc. The key targets involved IL-6, TP53, MAPK1, APP, VEGFA, TNF, etc. The results of enrichment analysis showed that there were 479 items related to GO function, including inflammation and stress reaction, immune response, signal transduction and so on. There were 121 KEGG related pathways, including Toll-like receptor signaling pathway, TNF signaling pathway, HIF-1 signaling pathway and PI3K/Akt signaling pathway. Conclusion Yinqiao Powder mainly had effects on IL-6, TP53, MAPK1, TNF and other core targets, and played a role in the treatment of upper respiratory tract infections through anti-inflammatory, antiviral and immunoregulation pathways.