Objective The present study aimed to investigate whether Chinese medicine could treat non-alcoholic fatty liver disease(NAFLD) by regulating SREBPs related targets through Meta analysis. Methods This paper analyzed relevant literatures through China Knowledge Network, Wanfang database, Weipu.com, PubMed database and Embase database. Results 18 articles were included, Meta analysis showed that compared with model group, the Chinese medicine group could significantly reduce serum triglyceride(TG)(P<0.000 1), total cholesterol(TC)(P<0.000 01), low-density lipoprotein( LDL-C)(P<0.000 01), ALT(alanine aminotransferase)(P<0.000 01), AST(aspartate aminotransferase)(P<0.000 01), HOMA-I(insulin resistance index)(P<0.000 01), and inhibited SREBP-1c mRNA(P<0.000 01), while had no significant effect on high-density lipoprotein(HDL-C)(P=0.06). Conclusion This Meta analysis study found that Chinese medicine could reduce blood lipids, improve liver function and treat NAFLD in rat model by regulating SREBP-1c related targets, thus provide pharmacological basis for guiding the research and development of clinical drugs and traditional Chinese medicine preparations.