Objective To analyze and summarize Fang Wenyan’s treatment of breast cancer medication and prescription rules. Methods Collecting Fang Wenyan to treat prescriptions for female breast cancer clinics, and using The Traditional Chinese Medicine Inheritance Auxiliary Platform to explore the characteristics and prescriptions of breast cancer treatment. Results A total of 184 prescriptions were included, involving 200 kinds of Chinese herbal medicines. The frequency of prescription medications, common drug pairs, Nature and Flavour and Meridian Tropism were analyzed. Among them, 32 kinds of high frequency drugs with frequency(≥35) are used, and the top five Chinese herbal medicines are Bupleurum, Pinellia, Oyster, Astragalus membranaceus and Angelica sinensis. There are 109 pairs of medicines with support of 50, confidence of 0.97 and frequency(≥50). The top three pairs of high-frequency drugs are Pinellia-Scutellaria baicalensis, Pinellia-licorice and Pinellia-Angelica sinensis.Four Natures are mainly cold, Five Flavors are bitterness and sweetness, the Meridian Tropism are mainly liver and spleen meridians. Finally, 16 core combinations and 8 new prescriptions were excavated. Conclusion Fang Wenyan mainly treats breast cancer by strengthening body resistance , dispersing stagnated Liver-Qi, strengthening spleen and dredging collaterals, which embodies his academic thought of “supporting the righteousness, eliminating evils and dredging collaterals”.