Objective To evaluates the efficacy and safety of soothing liver method in the treatment of epilepsy by Meta-analysis. Methods A computerized search of eligible randomized controlled clinical trials in the Cochrane Library, PubMed, Wanfang Database, Weipu, and China Knowledge Network(CNKI) was performed. The search period was from the establishment of the database to December 2019. After obtaining relevant data,Meta analysis was conducted using RevMan 5.3 software. Results Eight randomized controlled trials were included in this article, with a total of 670 patients, including 341 in the test group and 329 in the control group. The results of Mate analysis of soothing liver method combined with antiepileptic drugs for epilepsy show that its clinical efficacy is better than that of antiepileptic drugs alone. Compared with the control group, EEG improvement rate, frequency of seizures, and quality of life of patients with epilepsy(QOL-31) were significantly improved, and the difference was statistically significant (P<0.05). Compared with the conventional treatment of epilepsy in western medicine, Liver-soothing method had fewer adverse reactions in the treatment of epilepsy. Conclusion Liver-soothing method combined with antiepileptic drugs has excellent clinical efficacy in treating epilepsy, and has few adverse reactions. However, due to the low quality of the included studies, this conclusion needs to be verified by more high-quality studies.