Objective To investigate the clinical effect of acupoint application combined with Rupixiao on breast hyperplasia patients of stagnation of liver qi and phlegm coagulation. To explore the advantages of TCM intervention.Methods Randomly divide 60 patients into 2 groups: control group orally taken Rupixiao, observation group combine with acupoint application of Chinese Herbal Medicine on the basis of the control group , compared the clinical efficacy of the two groups before and after treatment, as well as changes in sex hormone levels. Results The total effective rate of observation group are significantly higher than control group（P＜0.05）. The score of TCM clinical syndrome was improved, and observation group was superior.After treatment，E2 and PRL levels were decreased and P and FSH levels were increased in both groups（P＜0.05）,while the increase level of FSH in the observation group was more significant（P＜0.01）. Conclusion Acupoint application of Chinese Herbal Medicine Combined with Rupixiao can improve the clinical symptoms of breast hyperplasia patients of stagnation of liver qi and phlegm coagulation by regulating sex hormone. It is effective and easy to comply, its significant effect worth clinical promotion.