Objective To analyze the rules of syndrome differentiation and compatibility of all prescription preparations containing Radix Aucklamdias in Ministry of Public Health Drug Stangard·TCM Set Prescription preparation, so as to provide a reference for the clinical application of Radix Aucklamdias and the research and development of related proprietary medicines. Methods Based on the Traditional Chinese Medicine Inheritance Support Platform V2.5, data mining methods ,such as complex system entropy clustering,Apriori association rule algorithm and improved mutual information method were used to count the common drugs in the set formulation preparations containing Radix Aucklamdias,and the prescription rules and core drug combinations were analyzed. Results There were a total of 451 set prescription preparations containing Radix Aucklamdias,106 kinds of main syndromes,128 kinds of main diseases and 7 pairs of core combinations. Among them, the high frequency syndromes were the syndrome of food retention and the syndrome of Qi stagnation and blood stasis, and its core drug combinations are Muxiang Shunqi Powder and Xiangfu Siwu Decoction.The principal diseases of high frequency are accumulated stagnation and abdominal pain,and the corresponding core drug combinations were Muxiang Shunqi Powder and Xiangsha Liujunzi Decoction respectively. Conclusion The set prescription preparations containing Radix Aucklamdias in Ministry of Public Health Drug Stangard·TCM Set Prescription preparation, is the most widely used in digestive diseases, but seldom used in other aspects.The treatment of the syndrome of food retention and the disease of accumulation stagnation is both based on Muxiang Shunqi Powder.To treat the syndrome of Qi stagnation and blood stasis and abdominal pain, the basic prescription is Xiangfu Siwu Decoction and Xiangsha Liujunzi Decoction.The clinical application of Muxiang and the research and development of related new drugs in anti-inflammatory, anti-bacterial and anti-tumor fields still need to be further studied.