In this article, it is concluded from the etymological study that “six exogenous pathogens (Liu Yin)” are intangibly invasive, and the etiological basis of pathogenic wind(Feng Xie) is “worm”. Then based on modern understandings, it is concluded that the “worm” mainly includes invisible microorganisms and macromolecular particles. Because macromolecular particles exist in traditional Chinese medicine injections(TCMIs), it can be concluded that the adverse reactions caused by TCMIs have the attribute of pathogenic wind by comparing the characteristics of adverse reactions of TCMIs with those of pathogenic wind. Of course, the pathogenic factors are macromolecular impurities. This article also puts forward a theoretical reference for the prevention and treatment of pathogenic wind and adverse reactions of TCMIs.