Objective To evaluate the efficacy and safety of therapy of compound Chinese medicine in infantile dyspepsia. Methods The following keywords were used: dyspepsia, Stagnation, Chinese medicine, etc. Literatures were searched from Pubmed, Cochrane Library, CNKI, VIP, CBM and Wanfang Database. After studies being selected, the data of them was extracted. ROB assessment was utilized to evaluate the quality of eligible studies and Meta-analysis was performed with RevMan5.3 and Stata15. Results ①The result of Meta-analysis demonstrated that a more superior total effective rate of TCM group was observed when compared with western medicine group in the treatment of infantile dyspepsia[OR=2.51, 95%CI(1.75, 3.59), P<0.05], but not more superior than that of external therapies group[OR=0.21, 95%CI(0.12, 0.37), P<0.05]. When utilizing the meta-analysis of ordinal categorical variable, there was no significant enhancement of the effect degree between the group with the therapy of compound Chinese medicine and the group not with it. ②Compound Chinese medicine was more superior than other therapies in reducing the clinical symptom score of appetite [WMD=0.59, 95%CI(0.40, 0.78), P<0.05], but it was not remarkably superior for the aspect of other score. Conclusion The therapy of compound Chinese medicine shows a lower total percentage of effectiveness than external therapies, but higher than western medicine. Compared with other therapies, compound Chinese medicine appears to reduce the clinical symptom total score of appetite.