Objective A systematic review of randomized controlled trials of migraine treatment with wind-dispersing and heat-clearing method. CNKI, Wanfang, PubMed, The Cochrane Library database were searched from the inception to June 2019. RCTs of wind-dispersing and heat-clearing method for migraine were collected. Two investigators independently screened the articles, extracted the data, and evaluated the risk of bias of the included studies. The risk assessment was based on the bias risk assessment tool recommended by Cochrane 5.2.3, and Meta-analysis was performed using RevMan5.3 software. 8 RCTs were included, all of which reported clinical efficacy, suggesting that the wind-dispersing and heat-clearing method[RR=1.19, 95% CI(1.13, 1.26), P<0.000 01] is more effective compared with using western medicine alone; two studies have reported blood flow changes of MCA And PCA, suggesting that the improvement of MCA blood flow changes by wind-dispersing and heat-clearing method is better than that of using western medicine alone, and the improvement of PCA blood flow changes[RR=-1.01, 95%CI(-2.65, 0.63), P=0.23] had no significant statistic difference compared with western medicine treatment alone. Three studies reported adverse reactions such as dry mouth, diarrhea, and sleep changes in individual patients, and three studies reported no adverse events. However, due to the limitations of the number and quality of studies included, its clinical efficacy and safety are subject to more high-quality studies.