The severe acute respiratory syndrome coronavirus 2 infected pneumonia（referred to as "COVID-19"）belongs to the category of "epidemic disease" in TCM. COVID-19 belongs to "cold and wet epidemic". treatise on Shang-han takes the six meridians as the program of syndrome differentiation and treatment.From the law of pathogenesis of the six meridians pathogenesis,this article combined the clinical practice of combating COVID-19 to set forth the law of pathogenesis of the six meridians of COVID-19 and to conduct stage differentiation and treatment, so as to be beneficial to the optimization of clinical diagnosis and treatment.