Objective To reveal the characteristics of syndrome differentiation of female coronary heart disease (CHD), and to provide reference for the prevention and treatment of CHD in TCM and the research and development of new Traditional Chinese Medicine (TCM) drugs. Methods The reports of CHD cases with definite diagnosis and treatment records in recent 15 years were collected and sorted out by gender, age, TCM Syndrome and the nature of disease. The distribution of TCM syndromes and diseases of CHD in Male, female and female patients of different ages were analyzed statistically. Results Qi deficiency and blood stasis Syndrome was the first in female patients, followed by chest-yang depression, qi-yin deficiency, liver-kidney Yin deficiency, heart-blood stasis, Qi stagnation and blood stasis the nature of disease were blood stasis, Qi deficiency, Yin deficiency and Qi stagnation Among the patients under 49 years old, Qi stagnation and blood stasis, Qi stagnation, chest-yang depression and heart-blood stasis were the most common, and Qi stagnation and blood stasis were the main nature of disease while Yin deficiency of liver and kidney was the most common in 49 ~ 60 years old, and the Yin deficiency was the most common nature of disease. Over 60 years old in patients with Qi Deficiency blood stasis, Qi and Yin deficiency is the first, and the main nature of disease were blood stasis, Qi deficiency. In male patients, phlegm-blood stasis was the main syndromes, blood stasis and qi stagnation were the top two. Conclusion The Constitution of TCM syndrome differentiation of CHD has sex difference, the constitution of syndrome differentiation of female patients has its own characteristics, and the constitution of syndrome differentiation of female patients in different age groups is different.