Objective To explore the action pathway of Shaoyao Gancao Decoction on hyperandrogenism in polycystic ovary syndrome by network pharmacology. Methods The active ingredients and targets of Shaoyao Gancao Decoction were screened by TCMSP database combined with oral bioavail ability(OB), drug-like property(DL), and half-life period(HL). Genecards, Drugbank,and OMIM databases were used to obtain the targets of hyperandrogenism in polycystic ovary syndrome. Chinese medicine-active ingredient-target visualization network map was built by Cytoscape 3.7.2 software. VENNY diagram was used to screen out common targets of drugs and diseases. The protein interaction network (PPI) was constructed by STRING online analysis tool. The David database performed GO enrichment analysis and KEGG pathways analysis for key targets. Results 83 active components were screened and quercetin, kaempferol, 7-methoxy-2-methyl isoflavone and formononetin were key compounds, 41 key targets such as MAPK3, MMP-9, STAT3, TNF, IL-6, and VEGFA were founded. KEGG analysis indicated that these targets involved in TNF, HIF-1, FoxO, Toll-like receptors signaling pathways. Conclusion The main compounds such as quercetin, kaempferol could act on TNF, HIF-1, Toll-like receptors signaling pathways through TNF, IL-6, STAT3, VEGFA to regulate glycolipid metabolism, protect vascular endothelium and participate in inflammatory response thus reduce androgen synthesis and play a role in treating hyperandrogenism in polycystic ovary syndrome.