Objective To compare the clinical efficacy of six types acupuncture therapy for diarrhea-predominant irritable bowel syndrome by using network Meta-analysis, so as to provide reference for clinical decision-making. Methods Literatures on six types acupuncture therapy for diarrhea-predominant irritable bowel syndrome were retrieved from the Cochrane Library, Pubmed, Web of Science, CNKI, Wanfang and VIP database according to the strategies, and the time range was from inception to July 2020. The two researchers conducted screening independently according to inclusion criteria and exclusion criteria. After data extraction and literature quality evaluation, ADDIS and Stata software was used to conduct network Meta-analysis. Results A total of 41 articles and 3 311 patients were included. The results of network meta-analysis showed that acupuncture, warm acupuncture, indirect moxibustion and heat-sensitive moxibustion were superior to western medicine and electric acupuncture in the effective rate of treatment of diarrhea-predominant irritable bowel syndrome. Similarly, warm acupuncture and moxibustion are better than acupuncture. Six types acupuncture therapy in the order from high to low of the effective rate in treating diarrhea-predominant irritable bowel syndrome were: indirect moxibustion, warm acupuncture,heat-sensitive moxibustion, acupuncture, moxibustion and electric acupuncture. Conclusion Among the six acupuncture treatments, the indirect moxibustion has the highest effective rate. However, due to the influence of the quantity and quality of the included literature, the conclusion remains to be further verified.