Objective To explore the Underlying mechanisms of Qingwen Jiere Mixture(QJM) for the treatment of corona virus desease 2019(COVID-19) by network pharmacology. Methods Compounds in QJM were screened using TCMSP database and relative researches.Uniprot database was used to search the corresponding genes of targets. Key targets in COVID-19 were retrieved from OMIM and Genecards database. The common potential targets between QJM and COVID-19 were imported into STRING database for PPI network. The Gene oncology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis of key targets was also conduct to generat the relative pathways based on DAVID and KOBAS3.0 database respectively. The compound-target-pathway network was established using Cytoscape 3.7.2. Results 264 active compounds and 510 targets were obtained from QJM in this study, and 32 candidates were identified which are the potential targets of QJM on COVID-19 after overlaiding， key targets include interleukin(il-6), tumor necrosis factor (TNF), chemokine ligand 2(CCL2), etc. GO functional enrichment analysis resulted in 283 GO entries, including 226 biological processes(BP) entries and 26 cellular component(CC) entries, and 31 molecular function(MF) entries. KEGG pathway enrichment analysis revealed that there were 232 signaling pathways involving IL-17 signaling pathway, Th17 cell differentiation and TNF signaling pathway. Conclusion In summary, our study corroborated the potential mechanisms of QJM on COVID-19. May be effective in the Qingwen Jiere Mixture composition affects the IL-6, the expression of TNF and CCL2, targets, and regulate the IL-17 signaling pathways, T cell receptor signaling pathways, Th17 cell differentiation, tumor necrosis factor signaling pathways, etc. Our study also provided the research fields to study the mechanisms of QJM on SARS-CoV-2 infection in future.