Objective To analyze the Composition Principles of Chinese patent drugs for Seminal Emission using TCM inheritance system. Methods The Chinese patent drugs treating seminal emission in the Dictionary of Traditional Chinese Medicine Prescriptions and National Standard for Chinese Patent Drugs enacted by Ministry of Public Health of China were collected and the composing principles were analized by using revised mutual information， complex system entropy clustering and so on based on the TCM inheritance system． Results A total of 170 prescriptions were collected. The main symptoms were kidney yang deficiency, kidney essence deficiency and kidney deficiency without consolidation. 242 kinds of Chinese herbs were involved, of which tonic berb was the most frequent, followed by astringent berb. The most frequently used herbs was warm nature; The main flavor was sweet, followed by pungent and bitter; It mainly belongs to kidney, liver and spleen meridians; There were 19 kinds of herbs with frequency more than 20%. The most frequently used single herb was Rehmannia glutinosa(50.29%). When the support degree was 20% and the confidence level was 0.6, there were 25 core drug combinations and 34 drug association rules. Through complex entropy cluster analysis, 10 core drug combinations and 5 new prescriptions were obtained. Conclusion The syndrome of kidney yang deficiency, kidney essence deficiency and kidney deficiency are the main syndrome in the treatment of seminal emission;The main treatment methods are tonifying kidney and strengthening essence, enriching kidney essence, supplemented by strengthening qi and nourishing blood;Zuogui pill is the main prescription in the treatment of seminal emission,It has certain reference significance for clinical treatment of seminal emission and new drug research and development.