Objective To summarize the application of Dayuanyin in the treatment of new coronary pneumonia,and to systematically evaluate the effectiveness of Dayuanyin in treating fever. Methods The PubMed, The Cochrane Library, EMbase, CNKI, WANFANG, VIP were searched up from the establishment of the library to April 4, 2020 and screened the randomized clinical controlled trial literature of Dayuanyin for the treatment of fever.Data extraction was performed by two reviewers and used Review Manager 5.3 to evaluate the sensitivity of the literature. At the same time, the third to eighth editions of the pneumonia diagnosis and treatment plan for the new coronavirus infection are sorted out, and the addition and subtraction plans for the recommended prescription Dayuanyin are analyzed and summarized. Results A total of 12 RCT documents were included, with a total of 2,398 cases.The results of systematic analysis show that the effective rate of the treatment group is significantly higher than that of the control group(RR=1.11, 95% CI[1.06,1.16], P=0.00). The treatment group was superior to the control group in terms of time to recovery of temperature and score of symptoms, the analysis results are statistically significant. The clinical heterogeneity of continuous variable data is too large for descriptive analysis only. Conclusion The effect of Dayuanyin combination therapy on fever is definite and the therapeutic effect is better than conventional therapy.